Romeo, MartinaCatalano, StefaniaMuzzalupo, Rita2026-04-142024-05-21http://hdl.handle.net/10955/5771Università della Calabria. Dipartimento di Farmacia e Scienze della Salute e della Nutrizione Dottorato in Medicina Traslazionale XXXVI cicloThe emergence of nanotechnology has not only revolutionized the field of drug formulation but has also ushered in a new era of personalized therapeutic interventions. Over the past few years, nanoscale-controlled release systems have emerged as gamechangers, exhibiting extraordinary potential in augmenting therapeutic effectiveness while concurrently mitigating the adverse effects associated with traditional medications. This novel cohort of nanocarriers, comprising a rich array of materials including lipids, polymers, and non-ionic surfactants, stands as a testament to the versatility and ingenuity of nanotechnological advancements. By harnessing their unique properties, nanovehicles offer a precision-targeted approach to drug delivery, homing in on specific pathological sites with unprecedented accuracy. Moreover, the inherent adaptability of nanocarriers allows for bespoke modifications tailored to individual therapeutic needs, whether it be bolstering drug stability, facilitating permeation across biological barriers, or orchestrating sophisticated "intelligent" systems for targeted cancer therapy. Not only does this approach promise to enhance therapeutic outcomes, but it also presents a more efficient and cost-effective alternative to the traditional pursuit of novel pharmacologically active compounds. As such, the convergence of nanotechnology and drug delivery represents a compelling frontier in the quest for optimized therapeutic interventions, holding profound implications for the future of medicine.enDrug deliveryniosomesliposomesThesis