Tesi di Dottorato
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Item Polymeric devices and nanomaterials for biomedical and pharmaceutical applications(2008-10-07) Cirillo, Giuseppe; Puoci, Francesco; Gabriele, BartoloItem Polimeri funzionali:aspetti strutturali, sintesi ed applicazioni nel settore tecnologico-farmaceutico(2007-11-16) Castiglione, Mariarosaria; Iemma, Francesca; Gabriele, BartoloItem Amino function and side chain modifications of amino acids, and synthesis of thrombin inhibiting peptides(2008-10-07) Viscomi, Maria Caterina; Liguori, Angelo; Gabriele, BartoloItem Sintesi di biomateriali a base di cellulosa derivatizzata(2008-10-07) Bloise, Ermelinda; Muzzalupo, Rita; Gabriele, BartoloItem Nuove strategie per la sintesi di peptidi e steroidi modificati(2007-11-16) Perri, Francesca; Loiguori, Angelo; Gabriele, BartoloItem Integrated membrane operations for the recovery of bioactive compounds from juice and by-products of the Citrus fruits production(2009-10-30) Liguori, Angelo; Cassano, Alfredo; Gabriele, Bartolo; Conidi, CarmelaItem Synthesis and application of new solid phase techniques in quantitative proteomics using MALDI and ESI mass spectrometry(2008-10-07) Moschidis, Petros; Giovanni Sindona, Giovanni; Gabriele, BartoloProteomics, the analysis of the protein complement of a cell or an organism has grown rapidly as a category of the life sciences. Mass spectrometry (MS) is one of the central detection techniques in proteome analysis, yet it has to rely on prior sample preparation steps that reduce the enormous complexity of the protein mixtures obtained from biological systems. For that reason, a number of tagging (or labeling) strategies have been developed that target specific amino acid residues or post-translational modifications, enabling the enrichment of subfractions via affinity clean up, resulting in the identification of an ever-increasing number of proteins. In addition, the attachment of stable isotope-labeled tags now allow the relative quantitation of protein levels of two samples, e.g. those representing different cell states, which is of great significance for drug discovery and molecular biology. This work presents the research for new stable isotope-labeled (as well as stable-isotope free) solid phase strategies for the identification and relative quantitation of complex protein mixtures using MALDI and ESI-MS, MS/MS technology.Item Sintesi di derivati benzofuranici e chinolinici mediante eterociclizzazione Pd-0 Cu-Catalizzata(2006) Mancuso, Raffaella; Gabriele, Bartolo; Salerno, Giuseppe; Sindona, GiovanniItem New challenges in the determination of food contaminants(2009-10-30) Attya, Mohamed; Gabriele, Bartolo; Di Donna, Leonardo